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The underlying mechanisms that result in opioid neurotoxicities are not well known. It is postulated that the accumulation and/or imbalance of active opioid metabolites are responsible for these syndromes. However, it is possible that the opioid parent compounds themselves may play a role. Further research is required to elucidate the causes and pathophysiological processes of these toxicities.
Clinical Presentation
Underlying Mechanisms
Assessment of toxicities
Overall management
Opioid rotation
Opioid dose reduction
Addition of other drugs
Hydration
References
Credits
Content for this flash card was provided by Dr. Jose Pereira and Jacqui Peden RN MN. For
full credits click here.