The underlying mechanisms that result in opioid neurotoxicities are not well known. It is postulated that the accumulation and/or imbalance of active opioid metabolites are responsible for these syndromes. However, it is possible that the opioid parent compounds themselves may play a role. Further research is required to elucidate the causes and pathophysiological processes of these toxicities.

[ Previous | Next ] in Opioid-related Neurotoxicity:

Clinical Presentation
Underlying Mechanisms
Assessment of toxicities
Overall management
Opioid rotation
Opioid dose reduction
Addition of other drugs
Hydration
References
Credits